EJMCR. 2020; 4(6): 186-189

An unusual complication of hepatitis A: secondary hemophagocytic lymphohistiocytosis

Authors: Jayant Kumar Muduli, Meenakshi Mitra, Shweta Agarwal, Supriya Rashmi.

ABSTRACT

Background: Secondary hemophagocytic lymphohistiocytosis (HLH) is characterized by severe cytopenias due to uncontrolled hemophagocytosis. Other laboratory signs and clinical symptoms result from disordered immune regulation, and cytokine storm is well recognized. It is often a fatal complication of infections. It is not as uncommon as thought of previously. Case Presentation: We discuss a 7-year-old boy, born out of non-consanguineous marriage with acute hepatitis A infection, who developed HLH during treatment and was successfully managed with methyl prednisolone pulse therapy followed by oral prednisone therapy. Conclusion: Secondary HLH is a rare complication in a case of hepatitis A. A high index of suspicion at the early stage of HLH may produce a favorable outcome.

Keywords:
Hemophagocytic lymphohistiocytosis, hepatitis A, injectable methyprednisolone, oral prednisolone, ferritin, triglycerides.


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An unusual complication of hepatitis A: secondary hemophagocytic lymphohistiocytosis


Authors
Jayant Kumar Muduli
Professor, Department of Pediatrics, IQ City Medical College and Narayana Multi-specialty Hospital, West Bengal, India
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Meenakshi Mitra
Assistant Professor, Department of Pediatrics, IQ City Medical College and Narayana Multispecialty Hospital, West Bengal, India
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Shweta Agarwal
Assistant Professor, Department of Pediatrics, IQ City Medical College and Narayana Multispecialty Hospital, West Bengal, India
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Supriya Rashmi
Senior Resident, Department of Pediatrics, IQ City Medical College and Narayana Multi-specialty Hospital, West Bengal, India
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Correspondence to:
. Meenakshi Mitra, Assistant Professor, Department of Pediatrics, IQ City Medical College and Narayana Multi-specialty Hospital, West Bengal, India.; mmmixie@gmail.com

Publication history
Received 30 Jul 2019
Revised 10 Apr 2020
Accepted 06 May 2020
Published online 25 Jun 2020
Published in print 09 Jul 2020

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Pubmed Style

Muduli JK, Mitra M, Agarwal S, Rashmi S. An unusual complication of hepatitis A: secondary hemophagocytic lymphohistiocytosis. EJMCR. 2020; 4(6): 186-189. doi:10.24911/ejmcr/173-1563277232


Web Style

Muduli JK, Mitra M, Agarwal S, Rashmi S. An unusual complication of hepatitis A: secondary hemophagocytic lymphohistiocytosis. https://www.ejmcr.com/?mno=57239 [Access: August 14, 2020]. doi:10.24911/ejmcr/173-1563277232


AMA (American Medical Association) Style

Muduli JK, Mitra M, Agarwal S, Rashmi S. An unusual complication of hepatitis A: secondary hemophagocytic lymphohistiocytosis. EJMCR. 2020; 4(6): 186-189. doi:10.24911/ejmcr/173-1563277232


Vancouver/ICMJE Style

Muduli JK, Mitra M, Agarwal S, Rashmi S. An unusual complication of hepatitis A: secondary hemophagocytic lymphohistiocytosis. EJMCR. (2020), [cited August 14, 2020]; 4(6): 186-189. doi:10.24911/ejmcr/173-1563277232


Harvard Style

Muduli, J. K., Mitra, . M., Agarwal, . S. & Rashmi, . S. (2020) An unusual complication of hepatitis A: secondary hemophagocytic lymphohistiocytosis. EJMCR, 4 (6), 186-189. doi:10.24911/ejmcr/173-1563277232


Turabian Style

Muduli, Jayant Kumar, Meenakshi Mitra, Shweta Agarwal, and Supriya Rashmi. 2020. An unusual complication of hepatitis A: secondary hemophagocytic lymphohistiocytosis. European Journal of Medical Case Reports, 4 (6), 186-189. doi:10.24911/ejmcr/173-1563277232


Chicago Style

Muduli, Jayant Kumar, Meenakshi Mitra, Shweta Agarwal, and Supriya Rashmi. "An unusual complication of hepatitis A: secondary hemophagocytic lymphohistiocytosis." European Journal of Medical Case Reports 4 (2020), 186-189. doi:10.24911/ejmcr/173-1563277232


MLA (The Modern Language Association) Style

Muduli, Jayant Kumar, Meenakshi Mitra, Shweta Agarwal, and Supriya Rashmi. "An unusual complication of hepatitis A: secondary hemophagocytic lymphohistiocytosis." European Journal of Medical Case Reports 4.6 (2020), 186-189. Print. doi:10.24911/ejmcr/173-1563277232


APA (American Psychological Association) Style

Muduli, J. K., Mitra, . M., Agarwal, . S. & Rashmi, . S. (2020) An unusual complication of hepatitis A: secondary hemophagocytic lymphohistiocytosis. European Journal of Medical Case Reports, 4 (6), 186-189. doi:10.24911/ejmcr/173-1563277232


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