Background: Mesothelioma is a rare malignancy which is uniformly fatal without treatment. The standard of care for peritoneal mesothelioma is currently cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Recurrent disease after treatment is typically confined to the peritoneal cavity. Case Presentation: We present the case of a 34-year-old female with recurrent peritoneal mesothelioma in the left chest wall, 26 months after her initial CRS and HIPEC. The patient underwent excision of the chest wall excision with the removal of the lower ribs, CRS, and HIPEC. Histopathology confirmed epithelioid-type mesothelioma deposits in skeletal muscle and hyaline cartilage. Her recovery was uncomplicated, and she was planned for adjuvant radiotherapy postoperative. Conclusion: This case presents an unusual and rare site of the recurrence of malignant peritoneal mesothelioma. It highlights the difficulty in choosing the optimal management of such cases of recurrence and the role of surgery in these instances. In complex cases of recurrent peritoneal mesothelioma, we recommend a discussion within a multidisciplinary team to provide the optimal outcome for these patients.

Keywords: Mesothelioma, recurrence, surgery, case report