Novel coronavirus disease 2019 and combined autoimmune neutropenia and thrombocytopenia: a case report
Authors: Munaza Batool Rizvi, Shivanand S Medar
Background: Combined autoimmune neutropenia (AIN) and immune thrombocytopenia (ITP) is a rare disease that can present as extremely low neutrophil count and platelet count, respectively [1]. Case Presentation: We describe the first case, to the authors knowledge, of the novel SARS CoV-2 infection and combined AIN and ITP in a healthy 27-year-old male. Conclusion: Viruses have been known to trigger autoimmune diseases in people with genetic predisposition. We speculate that the patients selective IgM deficiency predisposed him to have autoimmune cytopenia, and SARS-COV-2 triggered him to acquire combined AIN and ITP. Our hypothesis is supported by a lack of evidence of malignancy, a normal morphology on the smear, and an immediate response to IVIG infusion with significant improvement in platelet and neutrophilic count.
Keywords: Coronavirus, COVID-19, IVIG, combined autoimmune neutropenia (AIN) and immune thrombocytopenia (ITP), virus induced autoimmunity.
Authors
Munaza Batool Rizvi
Pediatric Emergency Medicine Fellow, Division of Pediatric Emergency Medicine, Albert Einstein College of Medicine, Children’s Hospital at Montefiore, Bronx NY
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Shivanand S Medar
Attending Physician, Division of Pediatric Critical Care Medicine, Assistant Professor of Pediatrics, Albert Einstein College of Medicine, Children’s Hospital at Montefiore, Bronx NY.
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Correspondence to:
Munaza Batool Rizvi, Pediatric Emergency Medicine Fellow, Division of Pediatric Emergency Medicine, Albert Einstein College of Medicine, Children’ mbrizvii@gmail.com
Publication history:
Received 16 Nov 2020
Revised 04 Jan 2021
Accepted 01 Feb 2021
Published online 28 Feb 2021
Published in print 31 Mar 2021
Rizvi MB, Medar SS. Novel coronavirus disease 2019 and combined autoimmune neutropenia and thrombocytopenia: a case report. EJMCR. 2021; 5(3): 98-101. doi:
10.24911/ejmcr/173-1605526618
Rizvi MB, Medar SS. Novel coronavirus disease 2019 and combined autoimmune neutropenia and thrombocytopenia: a case report. https://www.ejmcr.com/?mno=2424 [Access: April 24, 2024]. doi:
10.24911/ejmcr/173-1605526618
Rizvi MB, Medar SS. Novel coronavirus disease 2019 and combined autoimmune neutropenia and thrombocytopenia: a case report. EJMCR. 2021; 5(3): 98-101. doi:
10.24911/ejmcr/173-1605526618
Rizvi MB, Medar SS. Novel coronavirus disease 2019 and combined autoimmune neutropenia and thrombocytopenia: a case report. EJMCR. (2021), [cited April 24, 2024]; 5(3): 98-101. doi:
10.24911/ejmcr/173-1605526618
Rizvi, M. B. & Medar, . S. S. (2021) Novel coronavirus disease 2019 and combined autoimmune neutropenia and thrombocytopenia: a case report. EJMCR, 5 (3), 98-101. doi:
10.24911/ejmcr/173-1605526618
Rizvi, Munaza Batool, and Shivanand S Medar. 2021. Novel coronavirus disease 2019 and combined autoimmune neutropenia and thrombocytopenia: a case report. European Journal of Medical Case Reports, 5 (3), 98-101. doi:
10.24911/ejmcr/173-1605526618
Rizvi, Munaza Batool, and Shivanand S Medar. "Novel coronavirus disease 2019 and combined autoimmune neutropenia and thrombocytopenia: a case report." European Journal of Medical Case Reports 5 (2021), 98-101. doi:
10.24911/ejmcr/173-1605526618
Rizvi, Munaza Batool, and Shivanand S Medar. "Novel coronavirus disease 2019 and combined autoimmune neutropenia and thrombocytopenia: a case report." European Journal of Medical Case Reports 5.3 (2021), 98-101. Print. doi:
10.24911/ejmcr/173-1605526618
Rizvi, M. B. & Medar, . S. S. (2021) Novel coronavirus disease 2019 and combined autoimmune neutropenia and thrombocytopenia: a case report. European Journal of Medical Case Reports, 5 (3), 98-101. doi:
10.24911/ejmcr/173-1605526618