An unusual complication of hepatitis A: secondary hemophagocytic lymphohistiocytosis
Authors: Jayant Kumar Muduli, Meenakshi Mitra, Shweta Agarwal, Supriya Rashmi
Background: Secondary hemophagocytic lymphohistiocytosis (HLH) is characterized by severe cytopenias due to uncontrolled hemophagocytosis. Other laboratory signs and clinical symptoms result from disordered immune regulation, and cytokine storm is well recognized. It is often a fatal complication of infections. It is not as uncommon as thought of previously. Case Presentation: We discuss a 7-year-old boy, born out of non-consanguineous marriage with acute hepatitis A infection, who developed HLH during treatment and was successfully managed with methyl prednisolone pulse therapy followed by oral prednisone therapy. Conclusion: Secondary HLH is a rare complication in a case of hepatitis A. A high index of suspicion at the early stage of HLH may produce a favorable outcome.
Keywords: Hemophagocytic lymphohistiocytosis, hepatitis A, injectable methyprednisolone, oral prednisolone, ferritin, triglycerides.
Authors
Correspondence to:
Meenakshi Mitra, Assistant Professor, Department of Pediatrics, IQ City Medical College and Narayana Multi-specialty Hospital, West Bengal, India mmmixie@gmail.com
Publication history:
Received 30 Jul 2019
Revised 10 Apr 2020
Accepted 06 May 2020
Published online 25 Jun 2020
Published in print 09 Jul 2020
Muduli JK, Mitra M, Agarwal S, Rashmi S. An unusual complication of hepatitis A: secondary hemophagocytic lymphohistiocytosis. EJMCR. 2020; 4(6): 186-189. doi:
10.24911/ejmcr/173-1563277232
Muduli JK, Mitra M, Agarwal S, Rashmi S. An unusual complication of hepatitis A: secondary hemophagocytic lymphohistiocytosis. https://www.ejmcr.com/?mno=57239 [Access: April 26, 2024]. doi:
10.24911/ejmcr/173-1563277232
Muduli JK, Mitra M, Agarwal S, Rashmi S. An unusual complication of hepatitis A: secondary hemophagocytic lymphohistiocytosis. EJMCR. 2020; 4(6): 186-189. doi:
10.24911/ejmcr/173-1563277232
Muduli JK, Mitra M, Agarwal S, Rashmi S. An unusual complication of hepatitis A: secondary hemophagocytic lymphohistiocytosis. EJMCR. (2020), [cited April 26, 2024]; 4(6): 186-189. doi:
10.24911/ejmcr/173-1563277232
Muduli, J. K., Mitra, . M., Agarwal, . S. & Rashmi, . S. (2020) An unusual complication of hepatitis A: secondary hemophagocytic lymphohistiocytosis. EJMCR, 4 (6), 186-189. doi:
10.24911/ejmcr/173-1563277232
Muduli, Jayant Kumar, Meenakshi Mitra, Shweta Agarwal, and Supriya Rashmi. 2020. An unusual complication of hepatitis A: secondary hemophagocytic lymphohistiocytosis. European Journal of Medical Case Reports, 4 (6), 186-189. doi:
10.24911/ejmcr/173-1563277232
Muduli, Jayant Kumar, Meenakshi Mitra, Shweta Agarwal, and Supriya Rashmi. "An unusual complication of hepatitis A: secondary hemophagocytic lymphohistiocytosis." European Journal of Medical Case Reports 4 (2020), 186-189. doi:
10.24911/ejmcr/173-1563277232
Muduli, Jayant Kumar, Meenakshi Mitra, Shweta Agarwal, and Supriya Rashmi. "An unusual complication of hepatitis A: secondary hemophagocytic lymphohistiocytosis." European Journal of Medical Case Reports 4.6 (2020), 186-189. Print. doi:
10.24911/ejmcr/173-1563277232
Muduli, J. K., Mitra, . M., Agarwal, . S. & Rashmi, . S. (2020) An unusual complication of hepatitis A: secondary hemophagocytic lymphohistiocytosis. European Journal of Medical Case Reports, 4 (6), 186-189. doi:
10.24911/ejmcr/173-1563277232