POEMS syndrome: atypical presentation and therapeutic consideration
Authors: Ayman S Abukamar, Majdi M Abu-Awida, Saeed M Abughazaleh, Ahmad R Abdallah, Hamza M Al-Zghool
Background: Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome is a rare plasma cell dyscrasia, which could be presented as treatment-resistant polyneuropathy before the emergence of other systemic complications. Case Presentation: A 43-year-old male patient presented with progressive lower limb weakness and difficulty in walking, in addition to erectile dysfunction. After the diagnosis of POEMS syndrome, the patient was treated according to the standardized chemotherapeutic regimen for multiple myeloma that includes lenalidomide, without considering the increased risk of thromboembolic complications given that the patient had decreased ambulation due to his polyneuropathy and polycythemia. This warrants a better treatment regimen for these patients to eliminate any possible episode of thromboembolic complications, which might become fatal in the future. Conclusion: Although rare, it was recommended that deep vein thrombosis risk and its link to the proper treatment plan in patients with POEMS syndrome should be studied further.
Keywords: Case report, POEMS, polyneuropathy, thromboembolic, polycythemia, lenalidomide
Authors
Correspondence to:
Saeed M Abughazaleh, Student at Medical School, Hashemite University, Jerash, Jordan saeedgazaleh1996@gmail.com
Publication history:
Received 16 Jun 2019
Revised 05 Feb 2020
Accepted 08 Feb 2020
Published online 29 Feb 2020
Published in print 12 Mar 2020
Abukamar AS, Abu-Awida MM, Abughazaleh SM, Abdallah AR, Al-Zghool HM. POEMS syndrome: atypical presentation and therapeutic consideration. EJMCR. 2020; 4(2): 65-69. doi:
10.24911/ejmcr/173-1560698497
Abukamar AS, Abu-Awida MM, Abughazaleh SM, Abdallah AR, Al-Zghool HM. POEMS syndrome: atypical presentation and therapeutic consideration. https://www.ejmcr.com/?mno=53023 [Access: April 18, 2024]. doi:
10.24911/ejmcr/173-1560698497
Abukamar AS, Abu-Awida MM, Abughazaleh SM, Abdallah AR, Al-Zghool HM. POEMS syndrome: atypical presentation and therapeutic consideration. EJMCR. 2020; 4(2): 65-69. doi:
10.24911/ejmcr/173-1560698497
Abukamar AS, Abu-Awida MM, Abughazaleh SM, Abdallah AR, Al-Zghool HM. POEMS syndrome: atypical presentation and therapeutic consideration. EJMCR. (2020), [cited April 18, 2024]; 4(2): 65-69. doi:
10.24911/ejmcr/173-1560698497
Abukamar, A. S., Abu-Awida, . M. M., Abughazaleh, . S. M., Abdallah, . A. R. & Al-Zghool, . H. M. (2020) POEMS syndrome: atypical presentation and therapeutic consideration. EJMCR, 4 (2), 65-69. doi:
10.24911/ejmcr/173-1560698497
Abukamar, Ayman S., Majdi M. Abu-Awida, Saeed M. Abughazaleh, Ahmad R. Abdallah, and Hamza M. Al-Zghool. 2020. POEMS syndrome: atypical presentation and therapeutic consideration. European Journal of Medical Case Reports, 4 (2), 65-69. doi:
10.24911/ejmcr/173-1560698497
Abukamar, Ayman S., Majdi M. Abu-Awida, Saeed M. Abughazaleh, Ahmad R. Abdallah, and Hamza M. Al-Zghool. "POEMS syndrome: atypical presentation and therapeutic consideration." European Journal of Medical Case Reports 4 (2020), 65-69. doi:
10.24911/ejmcr/173-1560698497
Abukamar, Ayman S., Majdi M. Abu-Awida, Saeed M. Abughazaleh, Ahmad R. Abdallah, and Hamza M. Al-Zghool. "POEMS syndrome: atypical presentation and therapeutic consideration." European Journal of Medical Case Reports 4.2 (2020), 65-69. Print. doi:
10.24911/ejmcr/173-1560698497
Abukamar, A. S., Abu-Awida, . M. M., Abughazaleh, . S. M., Abdallah, . A. R. & Al-Zghool, . H. M. (2020) POEMS syndrome: atypical presentation and therapeutic consideration. European Journal of Medical Case Reports, 4 (2), 65-69. doi:
10.24911/ejmcr/173-1560698497