Background: Salmonella infection usually causes mild self-limiting gastroenteritis. Nontyphoidal salmonella can sometimes cause bacteremia and extra-intestinal infection. In rare occasions, it can result in splenic abscess. Case Presentation: We reported a case of splenic abscess resulting from Salmonella enteritidis infection. Our patient is a 57-yearold man with diabetes mellitus, came with acute febrile illness associated with epigastric pain. He was diagnosed to have splenic abscess based on computed tomography and subsequently recovered well after antibiotic therapy and abscess drainage. Conclusion: Diagnosis of splenic abscess is often difficult and requires high index of suspicion. Early diagnosis is often associated with better outcome. Abscess drainage is an important treatment modality of splenic abscess.

Keywords: Nontyphoidal Salmonella, Salmonella enteritidis, Splenic abscess, antibiotic, drainage