EJMCR. 2020; 4(9): 301-304

False-positive high sensitivity troponin I on Alinity i

Authors: Fatima Zehra Kanani, Adnan Haider Kazmi.

ABSTRACT

Background: High sensitivity troponin I (Hs troponin I) is a precise and sensitive marker of myocardial injury. However, interferences by antibodies are not uncommon in immunoassays. Macrotroponin is one such phenomenon, in which immune complexes are formed between troponin and circulating antibodies, giving rise to false-positive results. Case Presentation: This is a case of a 30-year-old male with elevated high sensitivity troponin I results of 419 ng/l (99th percentile upper reference limit for males is 34.2 ng/l). The test was performed on Abbott Alinity i immunoassay analyzer (Abbott Gmbh & Co. KG, Wiesbaden, Germany). Electrocardiogram, exercise tolerance test, and echocardiogram were all unremarkable. The results of creatinine kinase-myocardial component, troponin T, and conventional troponin I on VITROS ECi Immunodiagnostics System (Ortho-Clinical Diagnostics, Rochester, NY) were within normal limits. Laboratory experiments were carried out to evaluate the case, and the investigations conducted indicated the presence of macrotroponins in the specimen, which demonstrated cross immunoreactivity with the Alinity (Abbott) assay but not with the VITROS (Ortho) assay. Conclusion: Clinicians and laboratorians should be aware of the possible interference by macrotroponin in their assays and should be alerted when there is a discordance between the laboratory and clinical findings.

Keywords:
Macrotroponin, cardiac biomarkers, autoantibody, heterophile antibody, immunoassay interferences, case report


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False-positive high sensitivity troponin I on Alinity i


Authors
Fatima Zehra Kanani
Section of Chemical Pathology, The Indus Hospital, Karachi, Pakistan
PubMed articlesGoogle scholar articles

Adnan Haider Kazmi
Section of Chemical Pathology, The Indus Hospital, Karachi, Pakistan
PubMed articlesGoogle scholar articles


Correspondence to:
. Fatima Zehra Kanani, Consultant Chemical Pathologist, The Indus Hospital, Karachi, Pakistan.; fatima.kanani@tih.org.pk

Publication history
Received 31 Mar 2020
Revised 19 Aug 2020
Accepted 14 Sep 2020
Published online 13 Oct 2020
Published in print 17 Oct 2020

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Pubmed Style

Kanani FZ, Kazmi AH. False-positive high sensitivity troponin I on Alinity i. EJMCR. 2020; 4(9): 301-304. doi:10.24911/ejmcr/173-1585218303


Web Style

Kanani FZ, Kazmi AH. False-positive high sensitivity troponin I on Alinity i. https://www.ejmcr.com/?mno=95145 [Access: October 23, 2020]. doi:10.24911/ejmcr/173-1585218303


AMA (American Medical Association) Style

Kanani FZ, Kazmi AH. False-positive high sensitivity troponin I on Alinity i. EJMCR. 2020; 4(9): 301-304. doi:10.24911/ejmcr/173-1585218303


Vancouver/ICMJE Style

Kanani FZ, Kazmi AH. False-positive high sensitivity troponin I on Alinity i. EJMCR. (2020), [cited October 23, 2020]; 4(9): 301-304. doi:10.24911/ejmcr/173-1585218303


Harvard Style

Kanani, F. Z. & Kazmi, . A. H. (2020) False-positive high sensitivity troponin I on Alinity i. EJMCR, 4 (9), 301-304. doi:10.24911/ejmcr/173-1585218303


Turabian Style

Kanani, Fatima Zehra, and Adnan Haider Kazmi. 2020. False-positive high sensitivity troponin I on Alinity i. European Journal of Medical Case Reports, 4 (9), 301-304. doi:10.24911/ejmcr/173-1585218303


Chicago Style

Kanani, Fatima Zehra, and Adnan Haider Kazmi. "False-positive high sensitivity troponin I on Alinity i." European Journal of Medical Case Reports 4 (2020), 301-304. doi:10.24911/ejmcr/173-1585218303


MLA (The Modern Language Association) Style

Kanani, Fatima Zehra, and Adnan Haider Kazmi. "False-positive high sensitivity troponin I on Alinity i." European Journal of Medical Case Reports 4.9 (2020), 301-304. Print. doi:10.24911/ejmcr/173-1585218303


APA (American Psychological Association) Style

Kanani, F. Z. & Kazmi, . A. H. (2020) False-positive high sensitivity troponin I on Alinity i. European Journal of Medical Case Reports, 4 (9), 301-304. doi:10.24911/ejmcr/173-1585218303


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