Rivaroxaban-induced skin necrosis: a case report
Authors: Mosaad Abelhameed Soliman, Khalid AbdelAziz Mowafy, Nashaat Abdrabo Elsaadany, Rana Ibraheem Soliman, Sameh Ibraheem Awad, Reem Ibraheem Soliman
Background: Even though rivaroxaban has been mainly associated with hemorrhage-related adverse effects, rivaroxaban-induced skin necrosis has received less attention or went unrecognized. Little has been documented about hypersensitivity reactions caused by the treatment with rivaroxaban. Case Presentation: This paper reports a skin necrosis with an apparent similarity to skin adverse events caused by the different anticoagulants. It happened in a 30-year-old female patient during rivaroxaban treatment. The correlation of the skin lesions to the used drug was made by the act of repeated discontinuation and reuse of rivaroxaban and the noticed remission and exacerbation of skin necrosis. Conclusion: This case highlights the vigilance required by healthcare in recognizing potential adverse effects of newly marketed drugs and in making medication changes whenever necessary.
Keywords: Rivaroxaban, adverse effects, anaphylaxis, hypersensitivity, skin necrosis.
Authors
Correspondence to:
Mosaad Soliman, Head of Vascular Surgery Department, Faculty of Medicine, Mansoura University, Egypt Soliman_mosaad@hotmail.com
Publication history:
Received 25 Apr 2019
Revised 01 Aug 2019
Accepted 01 Nov 2019
Published in print 15 Dec 2019
Soliman MA, Mowafy KA, Elsaadany NA, Soliman RI, Awad SI, Soliman RI, . Rivaroxaban-induced skin necrosis: a case report. EJMCR. 2019; 3(3): 112-115. doi:
10.24911/ejmcr/173-1555632293
Soliman MA, Mowafy KA, Elsaadany NA, Soliman RI, Awad SI, Soliman RI, . Rivaroxaban-induced skin necrosis: a case report. https://www.ejmcr.com/?mno=44358 [Access: March 28, 2024]. doi:
10.24911/ejmcr/173-1555632293
Soliman MA, Mowafy KA, Elsaadany NA, Soliman RI, Awad SI, Soliman RI, . Rivaroxaban-induced skin necrosis: a case report. EJMCR. 2019; 3(3): 112-115. doi:
10.24911/ejmcr/173-1555632293
Soliman MA, Mowafy KA, Elsaadany NA, Soliman RI, Awad SI, Soliman RI, . Rivaroxaban-induced skin necrosis: a case report. EJMCR. (2019), [cited March 28, 2024]; 3(3): 112-115. doi:
10.24911/ejmcr/173-1555632293
Soliman, M. A., Mowafy, K. A., Elsaadany, N. A., Soliman, R. I., Awad, S. . . I. ., Soliman, R. I. & (2019) Rivaroxaban-induced skin necrosis: a case report. EJMCR, 3 (3), 112-115. doi:
10.24911/ejmcr/173-1555632293
Soliman, Mosaad Abelhameed, Khalid AbdelAziz Mowafy, Nashaat Abdrabo Elsaadany, Rana Ibraheem Soliman, Sameh Ibraheem Awad, Reem Ibraheem Soliman, and . 2019. Rivaroxaban-induced skin necrosis: a case report. European Journal of Medical Case Reports, 3 (3), 112-115. doi:
10.24911/ejmcr/173-1555632293
Soliman, Mosaad Abelhameed, Khalid AbdelAziz Mowafy, Nashaat Abdrabo Elsaadany, Rana Ibraheem Soliman, Sameh Ibraheem Awad, Reem Ibraheem Soliman, and . "Rivaroxaban-induced skin necrosis: a case report." European Journal of Medical Case Reports 3 (2019), 112-115. doi:
10.24911/ejmcr/173-1555632293
Soliman, Mosaad Abelhameed, Khalid AbdelAziz Mowafy, Nashaat Abdrabo Elsaadany, Rana Ibraheem Soliman, Sameh Ibraheem Awad, Reem Ibraheem Soliman, and . "Rivaroxaban-induced skin necrosis: a case report." European Journal of Medical Case Reports 3.3 (2019), 112-115. Print. doi:
10.24911/ejmcr/173-1555632293
Soliman, M. A., Mowafy, K. A., Elsaadany, N. A., Soliman, R. I., Awad, S. . . I. ., Soliman, R. I. & (2019) Rivaroxaban-induced skin necrosis: a case report. European Journal of Medical Case Reports, 3 (3), 112-115. doi:
10.24911/ejmcr/173-1555632293