EJMCR. 2020; 4(9): 280-284

Case report of intrahepatic cholangiocarcinoma showing thyroid like follicular pattern: a rare morphological variant

Authors: Ashini Shah, Brinda S. Chandibhamar, Amisha Gami, Priti Trivedi.

ABSTRACT

Background: Intrahepatic cholangiocarcinoma (ICC) is arising from the intrahepatic bile ducts and accounts for 8%-10% of all malignant hepatic tumors. Case Presentation: We report the case of a 42-year-old woman having ICC with thyroid-like follicular pattern. The patient had 9-cm solitary liver mass showing morphological pattern resembling thyroid follicles. Immunohistochemistry was negative for thyroid markers. The patient had no evidence of a previous or concomitant thyroid tumor. This case can be added to the list of extrathyroidal primary tumor that morphologically resembles thyroid neoplasms. Only three such cases have been previously reported in the literature. Such a pattern is known to occur in primary kidney and breast tumor. Thyroid like pattern broadens the morphological spectrum of cholangiocarcinoma. Conclusion: Careful evaluation of this morphological rare variant of ICC is very essential to prevent misdiagnosis of metastatic thyroid follicular neoplasm.

Keywords:
Cholangiocarcinoma, thyroid follicle-like pattern, thyroid transcription factor 1 (TTF-1).


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Case report of intrahepatic cholangiocarcinoma showing thyroid like follicular pattern: a rare morphological variant


Authors
Ashini Shah
Department of Oncopathology, Gujarat Cancer Research Institute, Civil Hospital, Ahmedabad, India
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Brinda S Chandibhamar
Department of Oncopathology, Gujarat Cancer Research Institute, Civil Hospital, Ahmedabad, India
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Amisha Gami
Department of Oncopathology, Gujarat Cancer Research Institute, Civil Hospital, Ahmedabad, India
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Priti Trivedi
Department of Oncopathology, Gujarat Cancer Research Institute, Civil Hospital, Ahmedabad, India
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Correspondence to:
. Brinda S. Chandibhamar, Senior Resident, Department of Oncopathology, Gujarat Cancer Research Institute, Civil Hospital, Ahmedabad, India.; bschandibhamar@gmail.com

Publication history
Received 07 Apr 2019
Revised 13 Jul 2020
Accepted 03 Sep 2020
Published online 06 Oct 2020
Published in print 17 Oct 2020

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Pubmed Style

Shah A, Chandibhamar BS, Gami A, Trivedi P. Case report of intrahepatic cholangiocarcinoma showing thyroid like follicular pattern: a rare morphological variant. EJMCR. 2020; 4(9): 280-284. doi:10.24911/ejmcr/173-1554056047


Web Style

Shah A, Chandibhamar BS, Gami A, Trivedi P. Case report of intrahepatic cholangiocarcinoma showing thyroid like follicular pattern: a rare morphological variant. https://www.ejmcr.com/?mno=40750 [Access: October 23, 2020]. doi:10.24911/ejmcr/173-1554056047


AMA (American Medical Association) Style

Shah A, Chandibhamar BS, Gami A, Trivedi P. Case report of intrahepatic cholangiocarcinoma showing thyroid like follicular pattern: a rare morphological variant. EJMCR. 2020; 4(9): 280-284. doi:10.24911/ejmcr/173-1554056047


Vancouver/ICMJE Style

Shah A, Chandibhamar BS, Gami A, Trivedi P. Case report of intrahepatic cholangiocarcinoma showing thyroid like follicular pattern: a rare morphological variant. EJMCR. (2020), [cited October 23, 2020]; 4(9): 280-284. doi:10.24911/ejmcr/173-1554056047


Harvard Style

Shah, A., Chandibhamar, . B. S., Gami, . A. & Trivedi, . P. (2020) Case report of intrahepatic cholangiocarcinoma showing thyroid like follicular pattern: a rare morphological variant. EJMCR, 4 (9), 280-284. doi:10.24911/ejmcr/173-1554056047


Turabian Style

Shah, Ashini, Brinda S. Chandibhamar, Amisha Gami, and Priti Trivedi. 2020. Case report of intrahepatic cholangiocarcinoma showing thyroid like follicular pattern: a rare morphological variant. European Journal of Medical Case Reports, 4 (9), 280-284. doi:10.24911/ejmcr/173-1554056047


Chicago Style

Shah, Ashini, Brinda S. Chandibhamar, Amisha Gami, and Priti Trivedi. "Case report of intrahepatic cholangiocarcinoma showing thyroid like follicular pattern: a rare morphological variant." European Journal of Medical Case Reports 4 (2020), 280-284. doi:10.24911/ejmcr/173-1554056047


MLA (The Modern Language Association) Style

Shah, Ashini, Brinda S. Chandibhamar, Amisha Gami, and Priti Trivedi. "Case report of intrahepatic cholangiocarcinoma showing thyroid like follicular pattern: a rare morphological variant." European Journal of Medical Case Reports 4.9 (2020), 280-284. Print. doi:10.24911/ejmcr/173-1554056047


APA (American Psychological Association) Style

Shah, A., Chandibhamar, . B. S., Gami, . A. & Trivedi, . P. (2020) Case report of intrahepatic cholangiocarcinoma showing thyroid like follicular pattern: a rare morphological variant. European Journal of Medical Case Reports, 4 (9), 280-284. doi:10.24911/ejmcr/173-1554056047


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